Acne
Supporting the internal factors associated with inflammatory breakouts — sebum regulation, inflammatory signalling and the gut-skin axis.
The biological basis of acne — and how internal support fits alongside treatment.
Acne is influenced by both surface events and internal biological function. While topical products and prescription treatments act primarily at the skin’s surface, the processes that drive breakouts are governed by underlying biology — sebum production, the way cells lining the follicle shed and renew, the balance of skin microorganisms, and inflammatory signalling in and around the follicle.
Dermatology literature describes acne as a multifactorial condition in which these processes interact. Increasingly, internal factors are recognised as part of the picture — inflammatory and oxidative balance, micronutrient status relevant to skin repair, and the gut-skin axis — together shaping the internal environment in which the skin regulates oil, manages inflammation and repairs.
The Acne formulation is designed to support the internal cofactors these processes depend on — providing a consistent internal foundation that sits alongside a patient’s topical or prescribed treatment, not in place of it.
What’s in the Acne formulation — and why
This formulation represents the standard base composition for acne-prone skin, designed for general clinical use and practitioner-led recommendation.
Each active is included at a defined dose for its documented role in a pathway relevant to acne — calibrated to levels supported by published evidence, and a key advantage of pharmacist compounding over standardised manufactured supplements.
| Ingredient | Primary pathway relevance | Mechanism | Evidence summary | Key reference |
|---|---|---|---|---|
| Polydatin50 mg | Inflammatory signalling; skin defence | Modulates keratinocyte inflammatory signalling and antimicrobial peptide production | Laboratory studies in human keratinocytes demonstrate modulation of inflammatory pathways and increased β-defensin production relevant to acne | Ravagnan G et al. Inflammation. 2013;36(1):26–34 |
| Alpha lipoic acid150 mg | Inflammatory; oxidative pathways | Antioxidant that reduces inflammatory mediator expression in sebocytes | In cultured human sebocytes, alpha lipoic acid reduced expression of inflammatory mediators linked with acne biology | Lee WJ et al. Annals of Dermatology. 2019;31(1):84–87 |
| Selenomethionine50 mcg (selenium 20 mcg) | Antioxidant defence | Cofactor for glutathione peroxidase and antioxidant enzymes | Systematic review reports lower selenium status in acne, consistent with its antioxidant enzyme role | Lv J et al. Journal of Trace Elements in Medicine and Biology. 2020;62:126548 |
| Vitamin B5 (pantothenic acid)10 mg | Skin lipid metabolism | Precursor to coenzyme A supporting fatty-acid metabolism | A randomised trial of high-dose pantothenic acid reported reduced acne lesions; included here as a nutritional cofactor for skin lipid metabolism | Yang M et al. Dermatology and Therapy. 2014;4(1):93–101 |
| Zinc picolinate50 mg (elemental zinc ~10 mg) | Inflammatory lesion support | Contributes to immune regulation and inflammatory control | Systematic review and meta-analysis demonstrate zinc’s role in reducing inflammatory acne lesions, as monotherapy or adjunct | Yee BE et al. Dermatologic Therapy. 2020;33(6):e14252 |
| Vitamin A1000 IU | Epithelial differentiation | Regulates keratinocyte differentiation and follicular renewal | Adequate vitamin A status supports normal follicular keratinisation; lower levels are associated with acne severity | El-Akawi Z et al. Clinical and Experimental Dermatology. 2006;31(3):430–434 |
| Vitamin D3 (cholecalciferol)1000 IU | Immune regulation; inflammation | Modulates innate immune and inflammatory signalling in skin | A randomised controlled trial found vitamin D reduced inflammatory acne lesions in deficient patients | Lim SK et al. PLOS One. 2016;11(8):e0161162 |
| Vitamin E100 IU | Antioxidant defence | Lipid-soluble antioxidant protecting skin lipids from oxidation | Lower vitamin E status is associated with acne severity; protects skin lipids from oxidative damage | El-Akawi Z et al. Clinical and Experimental Dermatology. 2006;31(3):430–434 |
References describe the pathway and supporting evidence relevant to each ingredient. This formulation supports the biological processes associated with acne and is not intended to diagnose, treat, cure or prevent the condition.
Pharmaceutical-grade precision. Every ingredient has a purpose.
The Acne formulation is compounded by licensed Australian pharmacists within established TGA regulatory frameworks, using pharmaceutical-grade raw materials selected for documented roles in inflammatory regulation, antioxidant defence and skin repair.
The compounding approachTwo contexts, one formulation
The Acne formulation is designed to support skin from within as part of a patient’s daily routine. For patients managing ongoing or recurrent breakouts, it provides a consistent internal foundation targeting inflammatory and antioxidant balance and the factors associated with sebum regulation.
Topical and prescription acne therapies act on the skin’s surface and local follicular processes. This formulation supports the internal resources — inflammatory balance, micronutrient status and gut-skin factors — that sit beneath those surface processes, complementing existing treatment rather than replacing it.
Ready to order the Acne formulation for your clinic?
All formulations are compounded fresh to order and shipped directly to your clinic.